March 21, 2025
2025 NCAA Bracket Picks & Upsets
Explore expert bracket picks for the 2025 NCAA Tournament, including top upset predictions and Cinderella team picks. SportsLine's model simulates March Madness 10K times to predict the most accurate outcomes.
Updated
March 21, 2025
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NCAA Tournament 2025 Bracket Picks, Cinderella Teams & Top Upsets: Model Simulates March Madness 10K Times

March 12, 2025 – With the excitement of the 2025 NCAA Tournament just around the corner, SportsLine’s college basketball model has simulated the tournament 10,000 times to predict the most likely outcomes and top upsets. The model has proven to be incredibly accurate in recent years, correctly predicting 24 first-round upsets by double-digit seeds and outperforming over 91% of all CBS Sports brackets in four of the last six tournaments.

If you're preparing your own March Madness bracket, it's crucial to check out these predictions from SportsLine’s proven model, which has consistently nailed high-stakes picks such as UConn’s championship run in 2024 and Alabama’s Cinderella Final Four run as a 4-seed. Now, as the 2025 NCAA bracket is revealed, the model’s predictions are ready to help guide your bracket choices. Let’s dive into some of the key matchups and upset alerts to look out for this March Madness.

Iowa State’s Struggles Without Gilbert

Iowa State enters the 2025 NCAA Tournament without one of its top players, Keshon Gilbert, who is sidelined with a season-ending injury. Gilbert averaged over 13 points per game, and his absence is a major blow for the Cyclones. Iowa State faces No. 14 seed Lipscomb in the first round, and Lipscomb’s strong 3-point shooting makes them a potential upset pick in this matchup. The Cyclones will need to adapt quickly to keep their tournament hopes alive, but could Lipscomb pull off a first-round stunner?

Top Favorite Florida Eyes Blowout Win

No. 1 seed Florida is poised for a dominant first-round performance against No. 16 seed Norfolk State. Florida, one of the favorites to win it all, is expected to cruise through this matchup, and it’s easy to see why they’re one of the top picks in many 2025 March Madness brackets. But should they be your pick to cut down the nets in April? With the Gators’ deep roster and top-tier talent, they certainly have the potential to make a deep run, but March Madness is always full of surprises.

Key Matchups to Watch in the East Region

The East Region features some exciting matchups that are sure to keep basketball fans on the edge of their seats:

  • No. 8 Mississippi State vs. No. 9 Baylor: This game is expected to be one of the closest in the opening round. Mississippi State has struggled recently, losing five of their last seven games, but they are led by guard Josh Hubbard, who has been putting up an impressive 18.7 points per game. Baylor, on the other hand, brings in freshman guard VJ Edgecombe, who has had a stellar season, averaging 15 points per game and is projected to go high in the upcoming NBA Draft. With both teams dealing with their own challenges, this game could go either way.
  • No. 6 BYU vs. No. 11 VCU: Another exciting East Region game is the 6 vs. 11 matchup between BYU and VCU. BYU has an edge in terms of experience, having faced tougher competition during the regular season. VCU, meanwhile, is fresh off winning both the Atlantic 10 regular-season title and tournament championship, and they are no strangers to March Madness surprises, as evidenced by their shocking Final Four run in 2011. With both teams at the top of their game, expect this matchup to be tightly contested.
  • No. 3 Wisconsin vs. No. 14 Montana: Wisconsin, coming off a tough loss to Michigan in the Big Ten Tournament, will look to bounce back against Montana. The Badgers are led by John Tonje, who averages 19.2 points per game and is a Player of the Year candidate. Montana, making its 14th NCAA Tournament appearance, will be looking for its first tournament win since 2006. Although Wisconsin is the heavy favorite, Montana has a history of making waves in the tournament, and this game could surprise many.

Predicting the 2025 March Madness Upsets

One of the hallmarks of March Madness is the abundance of upsets, and the SportsLine model has been particularly adept at identifying these surprises. With its ability to simulate every game 10,000 times, the model has proven time and again that it knows how to spot potential Cinderella teams and bracket-busting results.

In addition to the Lipscomb-Iowa State matchup mentioned earlier, keep an eye on the BYU-VCU game, where VCU’s momentum could lead them to an upset victory. Montana’s chance at pulling off a win against Wisconsin should also be watched, as the Grizzlies have upset higher-seeded teams before.

The Key to Winning Your 2025 March Madness Pool

When filling out your 2025 March Madness bracket, it’s important to remember that the best picks aren’t just about the favorites — upsets and Cinderella runs are an integral part of the tournament. Relying on a model like SportsLine’s, which has a track record of success, can give you the edge you need to dominate your bracket pools. With its ability to predict upsets and make accurate simulations, you can feel confident about your picks.

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March 21, 2025
2025 NCAA Bracket Picks & Upsets
Explore expert bracket picks for the 2025 NCAA Tournament, including top upset predictions and Cinderella team picks. SportsLine's model simulates March Madness 10K times to predict the most accurate outcomes.
Updated
March 21, 2025

NCAA Tournament 2025 Bracket Picks, Cinderella Teams & Top Upsets: Model Simulates March Madness 10K Times

March 12, 2025 – With the excitement of the 2025 NCAA Tournament just around the corner, SportsLine’s college basketball model has simulated the tournament 10,000 times to predict the most likely outcomes and top upsets. The model has proven to be incredibly accurate in recent years, correctly predicting 24 first-round upsets by double-digit seeds and outperforming over 91% of all CBS Sports brackets in four of the last six tournaments.

If you're preparing your own March Madness bracket, it's crucial to check out these predictions from SportsLine’s proven model, which has consistently nailed high-stakes picks such as UConn’s championship run in 2024 and Alabama’s Cinderella Final Four run as a 4-seed. Now, as the 2025 NCAA bracket is revealed, the model’s predictions are ready to help guide your bracket choices. Let’s dive into some of the key matchups and upset alerts to look out for this March Madness.

Iowa State’s Struggles Without Gilbert

Iowa State enters the 2025 NCAA Tournament without one of its top players, Keshon Gilbert, who is sidelined with a season-ending injury. Gilbert averaged over 13 points per game, and his absence is a major blow for the Cyclones. Iowa State faces No. 14 seed Lipscomb in the first round, and Lipscomb’s strong 3-point shooting makes them a potential upset pick in this matchup. The Cyclones will need to adapt quickly to keep their tournament hopes alive, but could Lipscomb pull off a first-round stunner?

Top Favorite Florida Eyes Blowout Win

No. 1 seed Florida is poised for a dominant first-round performance against No. 16 seed Norfolk State. Florida, one of the favorites to win it all, is expected to cruise through this matchup, and it’s easy to see why they’re one of the top picks in many 2025 March Madness brackets. But should they be your pick to cut down the nets in April? With the Gators’ deep roster and top-tier talent, they certainly have the potential to make a deep run, but March Madness is always full of surprises.

Key Matchups to Watch in the East Region

The East Region features some exciting matchups that are sure to keep basketball fans on the edge of their seats:

  • No. 8 Mississippi State vs. No. 9 Baylor: This game is expected to be one of the closest in the opening round. Mississippi State has struggled recently, losing five of their last seven games, but they are led by guard Josh Hubbard, who has been putting up an impressive 18.7 points per game. Baylor, on the other hand, brings in freshman guard VJ Edgecombe, who has had a stellar season, averaging 15 points per game and is projected to go high in the upcoming NBA Draft. With both teams dealing with their own challenges, this game could go either way.
  • No. 6 BYU vs. No. 11 VCU: Another exciting East Region game is the 6 vs. 11 matchup between BYU and VCU. BYU has an edge in terms of experience, having faced tougher competition during the regular season. VCU, meanwhile, is fresh off winning both the Atlantic 10 regular-season title and tournament championship, and they are no strangers to March Madness surprises, as evidenced by their shocking Final Four run in 2011. With both teams at the top of their game, expect this matchup to be tightly contested.
  • No. 3 Wisconsin vs. No. 14 Montana: Wisconsin, coming off a tough loss to Michigan in the Big Ten Tournament, will look to bounce back against Montana. The Badgers are led by John Tonje, who averages 19.2 points per game and is a Player of the Year candidate. Montana, making its 14th NCAA Tournament appearance, will be looking for its first tournament win since 2006. Although Wisconsin is the heavy favorite, Montana has a history of making waves in the tournament, and this game could surprise many.

Predicting the 2025 March Madness Upsets

One of the hallmarks of March Madness is the abundance of upsets, and the SportsLine model has been particularly adept at identifying these surprises. With its ability to simulate every game 10,000 times, the model has proven time and again that it knows how to spot potential Cinderella teams and bracket-busting results.

In addition to the Lipscomb-Iowa State matchup mentioned earlier, keep an eye on the BYU-VCU game, where VCU’s momentum could lead them to an upset victory. Montana’s chance at pulling off a win against Wisconsin should also be watched, as the Grizzlies have upset higher-seeded teams before.

The Key to Winning Your 2025 March Madness Pool

When filling out your 2025 March Madness bracket, it’s important to remember that the best picks aren’t just about the favorites — upsets and Cinderella runs are an integral part of the tournament. Relying on a model like SportsLine’s, which has a track record of success, can give you the edge you need to dominate your bracket pools. With its ability to predict upsets and make accurate simulations, you can feel confident about your picks.

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2025 NCAA Tournament Bracket Predictions & Top Upsets
2025 NCAA Bracket Picks & Upsets

NCAA Tournament 2025 Bracket Picks, Cinderella Teams & Top Upsets: Model Simulates March Madness 10K Times

March 12, 2025 – With the excitement of the 2025 NCAA Tournament just around the corner, SportsLine’s college basketball model has simulated the tournament 10,000 times to predict the most likely outcomes and top upsets. The model has proven to be incredibly accurate in recent years, correctly predicting 24 first-round upsets by double-digit seeds and outperforming over 91% of all CBS Sports brackets in four of the last six tournaments.

If you're preparing your own March Madness bracket, it's crucial to check out these predictions from SportsLine’s proven model, which has consistently nailed high-stakes picks such as UConn’s championship run in 2024 and Alabama’s Cinderella Final Four run as a 4-seed. Now, as the 2025 NCAA bracket is revealed, the model’s predictions are ready to help guide your bracket choices. Let’s dive into some of the key matchups and upset alerts to look out for this March Madness.

Iowa State’s Struggles Without Gilbert

Iowa State enters the 2025 NCAA Tournament without one of its top players, Keshon Gilbert, who is sidelined with a season-ending injury. Gilbert averaged over 13 points per game, and his absence is a major blow for the Cyclones. Iowa State faces No. 14 seed Lipscomb in the first round, and Lipscomb’s strong 3-point shooting makes them a potential upset pick in this matchup. The Cyclones will need to adapt quickly to keep their tournament hopes alive, but could Lipscomb pull off a first-round stunner?

Top Favorite Florida Eyes Blowout Win

No. 1 seed Florida is poised for a dominant first-round performance against No. 16 seed Norfolk State. Florida, one of the favorites to win it all, is expected to cruise through this matchup, and it’s easy to see why they’re one of the top picks in many 2025 March Madness brackets. But should they be your pick to cut down the nets in April? With the Gators’ deep roster and top-tier talent, they certainly have the potential to make a deep run, but March Madness is always full of surprises.

Key Matchups to Watch in the East Region

The East Region features some exciting matchups that are sure to keep basketball fans on the edge of their seats:

  • No. 8 Mississippi State vs. No. 9 Baylor: This game is expected to be one of the closest in the opening round. Mississippi State has struggled recently, losing five of their last seven games, but they are led by guard Josh Hubbard, who has been putting up an impressive 18.7 points per game. Baylor, on the other hand, brings in freshman guard VJ Edgecombe, who has had a stellar season, averaging 15 points per game and is projected to go high in the upcoming NBA Draft. With both teams dealing with their own challenges, this game could go either way.
  • No. 6 BYU vs. No. 11 VCU: Another exciting East Region game is the 6 vs. 11 matchup between BYU and VCU. BYU has an edge in terms of experience, having faced tougher competition during the regular season. VCU, meanwhile, is fresh off winning both the Atlantic 10 regular-season title and tournament championship, and they are no strangers to March Madness surprises, as evidenced by their shocking Final Four run in 2011. With both teams at the top of their game, expect this matchup to be tightly contested.
  • No. 3 Wisconsin vs. No. 14 Montana: Wisconsin, coming off a tough loss to Michigan in the Big Ten Tournament, will look to bounce back against Montana. The Badgers are led by John Tonje, who averages 19.2 points per game and is a Player of the Year candidate. Montana, making its 14th NCAA Tournament appearance, will be looking for its first tournament win since 2006. Although Wisconsin is the heavy favorite, Montana has a history of making waves in the tournament, and this game could surprise many.

Predicting the 2025 March Madness Upsets

One of the hallmarks of March Madness is the abundance of upsets, and the SportsLine model has been particularly adept at identifying these surprises. With its ability to simulate every game 10,000 times, the model has proven time and again that it knows how to spot potential Cinderella teams and bracket-busting results.

In addition to the Lipscomb-Iowa State matchup mentioned earlier, keep an eye on the BYU-VCU game, where VCU’s momentum could lead them to an upset victory. Montana’s chance at pulling off a win against Wisconsin should also be watched, as the Grizzlies have upset higher-seeded teams before.

The Key to Winning Your 2025 March Madness Pool

When filling out your 2025 March Madness bracket, it’s important to remember that the best picks aren’t just about the favorites — upsets and Cinderella runs are an integral part of the tournament. Relying on a model like SportsLine’s, which has a track record of success, can give you the edge you need to dominate your bracket pools. With its ability to predict upsets and make accurate simulations, you can feel confident about your picks.

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